Micah Donovan

PhD Candidate

Research Advisor:

Donato Romagnolo

Research Topic:

Breast cancer epigenetics

Selected Publications:

Donovan MG, Selmin OI, Doetschman TC, Romagnolo DF. Epigenetic Activation of BRCA1 by Genistein In Vivo and Triple Negative Breast Cancer Cells Linked to Antagonism toward Aryl Hydrocarbon Receptor. Nutrients. 2019; Oct 23;11(11).

Donovan MG, Wren SN, Cenker M, Selmin OI, Romagnolo DF. Dietary fat and obesity as modulators of BC risk: Focus on DNA methylation. British Journal of Pharmacology. 2019 Nov 5. doi:10.1111/bph.14891. Review

Donovan MG, Selmin OI, Romagnolo DF. Aryl hydrocarbon receptor diet and breast cancer risk. Yale Journal of Biology and Medicine. 2018;91(2):105-127. Review

Donovan MG, Selmin OI, Doetschman TC, Romagnolo DF. Mediterranean Diet: Prevention of Colorectal Cancer. Frontiers in nutrition. 2017;4(59). Review

Romagnolo DF, Donovan MG, Papoutsis AJ, Doetschman TC, Selmin OI. Genistein prevents BRCA1 CpG methylation and proliferation in human breast cancer cells with activated aromatic hydrocarbon receptor. Current Developments in Nutrition. 2017;1(6):e000562.

Selmin OI, Donovan MG, Skovan B, Paine-Murieta GD, Romagnolo DF. Arsenic-induced BRCA1 CpG promoter methylation is associated with the downregulation of ERα and resistance to tamoxifen in MCF7 breast cancer cells and mouse mammary tumor xenografts. International Journal of Oncology. 2019.

Romagnolo DF, Donovan MG, Doetschman TC, Selmin OI. n-6 linoleic acid induced epigenetic alterations associated with colonic inflammation and cancer. Nutrients. 2019:11(7):171.

Selected Presentations:

American Association for Cancer Research, 2019, Atlanta, GA, Modulating effects of genistein in a mouse model of conditional BRCA1 heterozygous deletion and triple negative breast cancer cells.

American Institute for Cancer Research, 2019, Chapel Hill, NC, n-6 linoleic acid induces epigenetic alterations associated with colonic inflammation and cancer. 2019 American Institute for Cancer Research Conference.

American Association for Cancer Research, 2018, Chicago, IL, Galangin is an epigenetic modulator of BRCA1 and induces estrogen receptor alpha in triple negative breast cancer cells. 2018 American Association for Cancer Research Conference.

American Institute for Cancer Research, 2016, Bethesda, MD, Genistein reverses epigenetic silencing of BRCA1 in ER alpha-positive and -negative breast cancer cells with activated AhR.

Degrees

  • University of Arizona, MS, Nutritional Sciences, 2017
  • University of Arizona, BS, Nutritional Sciences, 2015